Factor V Leiden and Thrombophilia

Factor V Leiden Mutation Causing Thrombophilia

It has autosomal dominant inheritance and is the most common cause of inherited thrombophilia. FVL is the most prevalent thrombotic risk factor known in the Caucasian population (around 5%). [1] Heterozygotes have a three to five times increased risk of thrombosis. Homozygotes are much less common but have a much higher thrombotic risk, around eight times increased risk. It leads to a hypercoag...

Factor V Leiden Mutation Causing Thrombophilia

It has autosomal dominant inheritance and is the most common cause of inherited thrombophilia. FVL is the most prevalent thrombotic risk factor known in the Caucasian population (around 5%). [1] Heterozygotes have a three to five times increased risk of thrombosis. Homozygotes are much less common but have a much higher thrombotic risk, around eight times increased risk. It leads to a hypercoag...

Factor V Leiden in young patients with thrombophilia.

Factor V Leiden and genetic defects of thrombophilia in childhood porencephaly.

AIMS To determine to what extent the Arg506 to Gln point mutation in the factor V gene and further genetic factors of thrombophilia affect the risk of porencephaly in neonates and infants. METHODS The Arg506 to Gln mutation, factor V, protein C, protein S, antithrombin, antiphospholipid antibodies and lipoprotein (a) (Lp(a)) were retrospectively measured in neonates and children with porencep...

Factor V Leiden and Inflammation

Factor V Leiden, is a variant of human factor V (FV), also known as proaccelerin, which leads to a hypercoagulable state. Along these years, factor V Leiden (FVL) has been studied from the pathophysiologic point of view, and research has been focused on finding clinical approaches for the management of the FVL associated to a trombophilic state. Less attention has been paid about the possible r...